Which of the following is true for antibiotics that exhibit concentration-dependent bactericidal activity (eg, aminoglycosides, fluoroquinolones, daptomycin)?
Increasing their concentrations from levels slightly above the MIC to levels far above the MIC increases their rate of bactericidal activity.
The duration of these antibiotics' postantibiotic effect (PAE) is time-dependent.
If concentrations exceed the MIC, aminoglycosides and fluoroquinolones do not have a PAE on residual bacteria.
Aminoglycosides and fluoroquinolones are usually most effective as continuous infusions.
